Samantha "Sam" Arias is a Kryptonian worldkiller known as Reign, who was sent to Earth prior to Krypton's destruction. Sam is the single mother of Ruby Arias. She remained unaware of her origins until her powers started to manifest, leading to the emergence of one of strongest adversaries whom Supergirl ever had to face. Dr. Zoe Brockett, double board-certified doctor of pediatrics and critical care. A forthright, idealistic physician at Bunker Hill, and a positive life force. Trudy Cooper is the wife of Gordo Cooper, though they eventually divorce. She has an independent personality and is passionate about women's rights, and is also a registered pilot and owner of a courier service. Based on Lily Koppel's best-selling titular novel, which tells the real story. Dr. Jessica Adams is the last member to join House's Diagnostic Team. Originally, she was a prison doctor.